Enzymatic Toothpaste

What is Enzymatic Toothpaste?

Enzymatic toothpaste (brand name C.E.T., others) is a product used at home by pet owners to aid in tooth brushing that minimizes plaque and tartar formation on the exterior of the tooth (the crown), and also assists in the maintenance of good oral hygiene. It can be used on both dogs and cats.

Enzymatic toothpaste is sold over the counter (OTC), without a prescription, but should be used under your veterinarian’s direction. They can advise you on a complete oral hygiene program for your pet.

The U.S. Food and Drug Administration (FDA) does not review non-drug health products (e.g., herbals, nutraceuticals, shampoos, and other supplements) for safety or effectiveness before they are sold to the public. Manufacturers of non-drug health products must ensure their products are safe and labeled accurately. The FDA requires that these non-pharmaceuticals contain a disclaimer that says, “This product is not intended to diagnose, treat, cure or prevent any disease.” Health Canada licenses “veterinary health products” after reviewing safety, efficacy, and manufacturing information provided by the manufacturer. These products are not tested by Health Canada.

Your veterinarian is the best source of information about the safety of non-drug health products in pets. Just because a product is natural does not mean it is safe. All medicines and medicinal plants are potentially toxic if used inappropriately or given at high doses. Supplements can also have side effects, like pharmaceuticals. Few supplements and herbs have been subjected to rigorous scientific trials to determine their efficacy.

Although the information in this handout may be helpful, it may also be incomplete and may not represent the full range of effects the supplement could have on your pet.

How do I give my pet enzymatic toothpaste?

• Enzymatic toothpaste comes as a paste, in a squeezable tube.
• Use a soft-bristled toothbrush or finger brush to rub the toothpaste over the surface of your pet’s teeth.
• If you have difficulty getting your pet to allow toothbrushing, contact your veterinarian for tips to help with the procedure and reduce the stress of the treatment time for both you and your animal.

This fast-acting product should take effect quickly; however, effects may not be noted outwardly until several applications are completed.

What if I miss giving my pet a treatment?

If you miss a treatment, do it as soon as you remember. However, if it is almost time for the next scheduled treatment, skip the missed treatment and resume the regular schedule. Do not double up on applications to make up for a missed one.

Are there any potential side effects from enzymatic toothpaste?

There are no known side effects from enzymatic toothpaste. Drug sensitivities can develop over time with repeated exposure. Your pet may have no reaction after the first few doses but may develop a sensitivity later. It is important to watch for signs of an allergic reaction over the entire course of treatment. 

Other side effects may occur. If you notice anything unusual, contact your veterinarian immediately. This short-acting product should stop working within a few hours, although effects may be longer in pets with liver or kidney disease.

Are there any risk factors for this product?

• This product should NOT BE USED in pets who are allergic to it or to any of the ingredients in the product.
• C.E.T.^® Enzymatic Toothpaste is specially formulated for companion animal use and is safe for pets to swallow in small amounts.

Are there any drug interactions I should be aware of?

Certain medications may interact with enzymatic toothpaste and so it is important to tell your veterinarian about any medications (including vitamins, supplements, or herbal therapies) that your dog is taking before starting any new product use.

There are no documented drug interactions for enzymatic toothpaste. Enzymatic toothpaste is safe to use with tooth brushing, dental chews, and dental diets.

Is any monitoring needed with this product?

• At home, monitor for any abnormal changes. If any occur, discontinue the product and contact your veterinarian.
• Your veterinarian will let you know when they want to reassess your pet to ensure the product is working and not causing side effects.

How do I store enzymatic toothpaste?

• Keep out of the reach of children.
• Store at room temperature.
• See carton flap for lot number and expiration date.

What should I do in case of emergency?

If you suspect an overdose or an adverse reaction to the product, call your veterinary office immediately. If they are not available, follow their directions in contacting an emergency facility.